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KMID : 0363320070280020321
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Journal of Korean Oriental Internal Medicine
2007 Volume.28 No. 2 p.321 ~ p.332
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Anti-cancer Effects of Kamiboa-tang and some other Traditional Medical Prescriptions
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Sung Hyun-Jea
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Abstract
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Objectives : Anticancer and immune-modulating effects of several Korean medical prescriptions including Yukgunja-tang, Bohwa-tang, Sogam-Won, and Kamiboa-tang were investigated.
Methods : In vitro anti-cancer effects were measured by cytotoxicity MTT assay using SNU-1 gastric cancer cell lines, In vivo anti-cancer effects were measured by increased life span of S-180 sarcoma-injected ICR mouse. Immune-modulating effects were analyzed by measuring hemagglutinin titer, appearance of rosette forming cells, lymphocyte proliferation, and phagocytic index in methotrexate-pretreated mice.
Results : In vitro assay showed that only Sogam-won showed cytotoxic effect with IC_{50} of 87.9 {mu}g/ml. All other prescriptions showed no cytotoxic effects against SNU-1 gastric cancer cell line. However, in vivo assay showed that Sogam-won showed lowest anti-cancer effects in contrast to its highest cytotoxic effects, Kamiboa-tang, which showed no cytotoxic effect, showed the highest in vivo anticancer effects, with increased life span of 140%. Kamiboa-tang showed significant immune-enhancing activities by significantly increasing rosette forming cells, lymphocyte proliferation, and phagocytic index in methotrexate-pretreated mice (P<0.05).
Conclusion : The anticancer effect of Kamiboa-tang is not mediated by direct inhibition of cancer cells but is mediated by improving immune reactions against cancer cells.
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KEYWORD
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Anti-cancer, Cytotoxicity, Immune function, Korean Medical Prescription, Kamiboa-tang
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